Intermittent hypoxia can aggravate motor neuronal loss and cognitive dysfunction in ALS mice.
BackgroundPatients with ALS may be exposed to variable degrees of chronic intermittent hypoxia.However, all previous experimental studies on the effects of hypoxia in ALS have only used a sustained hypoxia model and it is possible that chronic intermittent hypoxia exerts effects via a different molecular mechanism from that of sustained hypoxia.No